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placebo), most of them (liraglutide, semaglutide SC, dulaglutide, albiglutide, and efpeglenatide) have also demonstrated a reduction in MACE with respect to placebo, while weekly exenatide or oral semaglutide showed a tendency to reduce MACE

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This process entails the oxidation of polyunsaturated fatty acids (PUFAs) within the sperm membrane, giving rise to harmful byproducts such as MDA and 4-HNE

Given the role of NAD + in modulating the processes described above, NAD + -boosting interventions are being investigated for supporting mitochondrial homeostasis