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Moving Beyond BMI: Percent Body Fat as a Better Measure Traditional metrics like BMI are being challenged by new research advocating for the use of percent body fat (%BF) as a more accurate indicator of health

GLP-1 receptor activation enhances glucose-dependent insulin secretion, suppresses inappropriate glucagon release, slows gastric emptying, and reduces appetite through central mechanisms

By this stage, most patients have completed a dose escalation schedule and feel stable on their maintenance dose

In the SURMOUNT-5 trial (comparing these drugs at weight-loss doses), more people discontinued semaglutide due to side effects (5.6%) than tirzepatide (2.7%)

In the past five years, these drugs have moved from diabetes clinics to mainstream medicine and for good reason