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In a post hoc analysis of the PLATO (Platelet Inhibition and Patient Outcomes) trial, which randomized patients with acute coronary syndrome to ticagrelor versus clopidogrel, ticagrelor reduced the incidence of the composite primary endpoint (cardiovascular death, myocardial infarction, or stroke within twelve months) consistently across subgroups of patients with diabetes and/or CKD, but with an increased absolute risk reduction in DM+/CKD+, while there was no increased risk of major bleeding with ticagrelor compared to clopidogrel in the subgroup of patients with DM+/CKD+.114 In a post hoc analysis of the GLOBAL-LEADERS trial, the effects of one-month dual antiplatelet therapy followed by 23-month ticagrelor monotherapy versus twelve-month dual antiplatelet therapy followed by twelve-month aspirin alone were analyzed according to DM/CKD status in patients undergoing percutaneous coronary intervention

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