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It is of interest to note that a class of tertiary -chloroacetamide-containing compounds such as RSL3 has previously been shown to induce a unique iron-dependent, oxidative, non-apoptotic cell death, selectively in KRAS-mutant cells, through covalently inhibiting glutathione peroxidase 4 (refs 34, 35, 36)
BD Biosciences)
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