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Research into more stable formulations and dual-action drugs could result in next-generation oral therapies with even greater efficacy
Based on patterns observed in clinical trials and the known pharmacology of the drug class, monitoring would likely need to be most intensive during the dose-escalation phase, when haemodynamic effects are most pronounced
Loss of insulin-like growth factor-1 signaling in astrocytes disrupts glutamate handling
It is not known whether this applies to humans
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