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Engineered probiotics expressing human BSH or 7 -dehydroxylase genes represent a next-generation approach
Results showed non-inferiority (Rybelsus did not increase cardiovascular risk vs placebo) but no significant reduction in MACE (Husain et al., Circulation, 2019)
The goal is weight loss AND improved health not weight loss at the expense of neurological symptoms
P = 0.84
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