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Water retention may stack early on

In the ATTAIN-MAINTAIN trial, 205 patients taking tirzepatide and 171 patients taking semaglutide were randomized to take orforglipron or placebo (no active drug) daily for a year

I also experienced suicidal thoughts and ideations toward the end of my treatment, but I didn't want my derm to pull me off the medsat that point in my life, I thought my skin was more important than my mental health, but I should have been upfront with my dermatologist ( I absolutely dont recommend this dangerous behavior, FYI )

SGLT2 inhibitors exert multiple effects, including activating autophagy and suppressing pyroptosis and ferroptosis, to mitigate tubular injury and kidney damage (119, 156, 205, 206)

Other reagents were of analytic grade unless mentioned otherwise