Clinical trials have focused on people living with obesity, early research shows it could, if licensed, be used for conditions like type 2 diabetes and fatty liver disease
However, more clinical research is required to validate these findings and investigate the long-term implications of using GLP-1RAs to treat male infertility because the precise pathways by which they affect male reproductive health are not entirely understood (101)
And that can backfire fast
To assess this, randomized trials typically evaluate the primary outcome of major adverse cardiovascular events (MACE), which includes cardiovascular death, non-fatal stroke, and non-fatal myocardial infarction (MI)
Increased heart rate is also a recognised class effect, and risks such as pancreatitis and gallbladder disease are associated with this drug class