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A plateau does not always mean the medication has failed
Ramachandran V, Arumugam T, Langley R, Hwang RF, Vivas-Mejia P, Sood AK, et al
Failing heart-relevant processes included increased uptake of long-chain fatty acids, impaired ATP production, cytosolic accumulation of deleterious lipid intermediates, impaired mitochondrial function, suppression of nutrient-deprivation signaling, cytosolic accumulation of amino acids driving aberrant mTOR activation, and inflammation-mediated functional iron deficiency with altered metabolism
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