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Given the smaller sample sizes available in non-European populations, we did not perform genome-wide association testing in these populations, and instead focused analyses on variants discovered as associated in the European GWAS
The most common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, abdominal pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss, and heartburn
In the most recent clinical trial, people taking the maximum dose of retatrutide, 12 mg, lost around 28% of their body weight on average, over the course of 80 weeks
6 Additional studies are currently under way to investigate if this effect is seen with other GLP-1 RAs
It is a first-in-class dual GLP-1 and GIP receptor agonist, meaning it targets two complementary metabolic pathways involved in blood sugar regulation, appetite control, and weight loss
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