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Nature 549 , 4853 (2017)
Bioavailability determines what percentage of the injected dose actually reaches systemic circulation
However, novel formulations have introduced oral tablets as viable administration methods
Use this formula: Concentration (mg/mL) = Vial Size (mg)BAC Water (mL) Example: a 10 mg vial reconstituted with 2 mL of BAC water yields 5 mg/mL
The carnitine shuttle system described above acts as a buffer for excess mitochondrial acetyl-CoA by transporting the acetyl group into the cytosol while releasing the CoA group in the mitochondrial matrix
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