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Insulin secretion increases in a glucose-dependent manner, meaning insulin rises only when blood sugar is elevated

Some observational data and animal model research has suggested GLP-1 receptor agonists may have direct bone-protective signaling effects that could modulate long-term fracture risk

2.3 Search strategy The literature was systematically searched for English articles published up to June 6, 2022 from the following databases which were PubMed, Embase, Web of Science and Cochrane Library