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The Patient Global Impression of Improvement (PGI-I) is another useful single-question measure

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For topical use, transient local reactions redness, stinging, burning, or itch are the expected category and are exactly what the ongoing Phase 2 trial is set up to measure (NCT07437586)

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Ice crystals form within the solution, physically shearing peptide bonds and denaturing the protein

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S3b), consistent with the low Fe loading of only 0.43% (Table S1)

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