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tirzepatide lowered HbA 1c by 2.01 to 2.30 percentage points versus 1.86 for semaglutide, meeting non-inferiority and superiority, with greater weight loss as well
Results showed dose-dependent weight loss: the 0.25mg dose produced 4.5% additional weight loss beyond diet and placebo, the 0.5mg dose achieved 9.2% weight loss, and the 1.0mg dose resulted in 10.6% weight lossrepresenting approximately twice the efficacy of other approved obesity drugs available at that time
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