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Doctors prescribe them to lower the risk of heart attack and stroke, manage blood sugar in diabetic and pre-diabetic patients, reduce dangerous pauses in breathing during sleep, and help people whose bodies due to illness, disability, or genetics cannot regulate weight on their own

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Fourth, the use of pseudo-observations at zero dose, while methodologically justified to stabilize model behavior at the lower boundary, represents a modeling assumption that may influence extrapolation outside the observed dose range