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PMC 6461196
Peptides have become increasingly popular in recent years, driven by the stratospheric rise of injectable GLP-1s for weight loss and a fleet of gray market peptides claiming to help with post-workout recovery, hormone balance, hair loss, and skin health
A pooled analysis of 5 randomized placebo-controlled trials demonstrated a significant 13% reduction in the risk of total stroke with GLP-1 RAs compared with placebo, without significant heterogeneity between trials
Keeping weight off after stopping semaglutide or another GLP-1 medication can be a challenge
Takeaway Jorge Plutzky, M.D., a Mass General Brigham cardiologist who was instrumental in designing and running the trial as a steering committee member, noted that the landmark study means semaglutide could help large numbers of patients with heart disease in the future
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