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In a European multi-center clinical study, supplementation with L-carnitine (in the form of propionyl-L-carnitine at 2 g/day for 12 months) in patients with moderate to severe claudication related to the maximum distance covered and the perceived quality of life achieved a significant improvement compared to patients who received only placebos

University of Washington, Seattle Shotelersuk V, Larson D, Anikster Y, McDowell G, Lemons R, Bernardini I, Guo J, Thoene J, Gahl WA (1998) CTNS mutations in an American-based population of cystinosis patients

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