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As a result, the long-term GI safety of these agents continues to be actively investigated
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A notable double-blind RCT in 262 elderly subjects found that NAC (600 mg twice daily) for 6 months significantly reduced influenza-like episodes only 25% of NAC-treated subjects who seroconverted to influenza A developed clinical symptoms, compared to 79% of placebo subjects (De Flora et al., Eur Respir J, 1997) [40]
The preclinical literature does not prominently describe heart rate elevation
others stay on a lower maintenance dose
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