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64 Methylene tetrahydrofolate dehydrogenases (MTHFD1 in cytosol and MTHFD2 or MTHFD2L in mitochondria) catalyze the oxidation of 5,10-methylene-THF (CH2-THF) to form 10-formyl-THF, and 10-formyl-THF dehydrogenases (ALDH1L1 in cytosol and ALDH1L2 in mitochondria) catalyze the oxidization of 10-formyl-THF to generate CO 2 with concomitant NADPH production
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It goes into the muscle instead of a vein, so it's simpler and quicker, more like a vaccine or a B12 shot than a drip
Oh, wow
A 24 h fasting period of WT or ob/ob mice, upregulated PPAR and PPAR-target genes related to mitochondrial (medium- and long-chain acyl-CoA dehydrogenases), peroxisomal (acyl-CoA oxidase (ACOX) 1 and enoyl-CoA hydratase), and cytochrome-mediated (CYP4A1 and CYP4A3) FAO [85]
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