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Adverse Reactions/Side Effects The following adverse reactions are discussed elsewhere: Hyperglycemia or Hypoglycemia with Changes in Insulin Regimen [see Warnings and Precautions (5.2)] Hypoglycemia [seeWarnings and Precautions (5.3)] Hypoglycemia Due to Medication Errors [see Warnings and Precautions (5.4)] Hypersensitivity Reactions [see Warnings and Precautions (5.5)] Hypokalemia [see Warnings and Precautions (5.6)] 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in clinical trials of a drug cannot be directly compared to rates in the clinical trial of another drug and may not reflect the rates observed in practice

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Some providers recommend spending extra time at 12.5 mg, perhaps six to eight weeks instead of four, before deciding whether the final increase to 15 mg is necessary

The canonical interpretation of the Warburg effect implies that cells bypass the mitochondrial respiratory chain for the synthesis of ATP even in the presence of adequate oxygen supply (Ganapathy et al., 2009)