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It is given in courses, and trials usually measured results at the end of a course and then at follow-up points, often 30 to 90 days later
1,3 *Efficacy estimand: This analysis was not included in the statistical testing hierarchy, and as such, is hypothetical and was not controlled for multiplicity
In knee OA, clinical data suggest that GLP-1RAs improve pain and function and reduce the risk of surgical intervention
Even when patients consult their doctors, as Ms
Think of it as holding a door open against a spring
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