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Patients with A1C 8% at screening had their background basal insulin dose reduced by 20% at the start of the trial to limit potential risk of hypoglycemia

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Its activity profile is best understood as systems-level: published in vitro and in vivo work has documented effects on fibroblast proliferation, collagen and growth-factor receptor expression, endothelial migration, nitric oxide system signalling, and dopamine and serotonin pathway markers

Rapid, dramatic losses (whether from surgery, drugs, or crash diets) increase the risk