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Now, Alexander notes, they're generic and often cost just a few bucks

According to the FDA label, nausea occurs in approximately 44% of patients, with vomiting, diarrhea, and constipation also frequently reported

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Despite binding to different receptors, their effects converge on protein kinases (PKA, PKB, PKC) and transcription factors like PPAR-gamma, a key regulator of lipid metabolism