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Residual TFA: Trifluoroacetic acid is a leftover from synthesis

A trend toward lower total cholesterol was observed, consistent with findings from larger clinical case series of individuals with MC4R deficiency and from MC4R mutation carriers in the UK Biobank population cohort (accompanying paper, Zorn et al

They do this by decreasing the activity of the protein breakdown pathway, and also by decreasing the expression of several complexes involved in protein breakdown