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After the treatment period, the mice were anesthetized with isoflurane (Isoflutek , Karizoo Laboratories) and blood from the portal and cava veins was retrieved in the presence of a DPP-IV inhibitor (20 L per mL of blood), after which the mice were euthanized by cervical dislocation
In new data published in Nature Medicine and presented at the European Congress on Obesity annual meeting, adults receiving semaglutide were able to maintain their weight reduction as well as a decrease in waist circumference and waist-to-height ratio for up to 4 years
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The trials were not designed to detect a difference in terms of these outcomes, and none of the analyses were controlled for multiplicity
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