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For instance, PDE4 inhibitors such as roflumilast, used in COPD, frequently induce gastrointestinal and CNS-related side effects, including diarrhea, nausea, headache, insomnia, and weight loss (Janjua et al., 2020
By influencing muscle loss and nitrogen balance in research models, these substances could provide further avenues for investigating the adverse side effects of glucocorticoid treatment
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