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They would need to carefully weigh the potential benefits against the risks for each individual patient

Unlike GLP-1 agonists such as semaglutide or tirzepatide, which work primarily through appetite suppression, AOD-9604 directly enhances fat metabolism at the cellular level through beta-3 adrenergic receptor modulation

The risk is particularly high in those with abdominal obesity (Pak 2016

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7 Although future studies will be required to fully characterize the structure of NAD + -associated human DNA Ligase IV, these findings reveal that like ATP, NAD + can serve as a provider of adenylation for DNA ligation in the NHEJ DNA repair pathway