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Since previous studies have linked the activation of NRF2 with the repression of lipogenic gene expression 64 , we reasoned that GSH depletion causes oxidation and consequent inactivation of KEAP1 (a repressor of NRF2), thus leading to increased antioxidant and decreased lipogenic gene expression

NAD(H) is mainly involved in catabolic reactions, 5,12,13 whereas NADP(H) is primarily involved in cellular antioxidative effects and anabolic reactions as shown in Fig

Preventing cancer progression Some research shows that glutathione has a role in preventing the progression of cancer

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It shifts melanin synthesis from eumelanin (dark pigment) to pheomelanin (light pigment), which results in a lighter skin tone