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This triple mechanism produced 24.2% mean weight reduction in Phase 2 trials, exceeding both comparators

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Results showed that semaglutide 1.0 mg once weekly produced superior HbA1c reductions (mean decrease of 1.5% from baseline) compared to exenatide, with patients also experiencing greater weight loss (average 5.6 kg over 56 weeks)

Statistical analyses The primary analysis estimand was the average treatment effect on the treated (ATT), estimated using a propensity score (PS) weighting approach in the on-treatment cohort

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