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discuss with doctor if severe Week 1316: Maintenance Dose (9mg or continuing to 12mg) For 9mg group (maintenance): Side effects stabilize Nausea decreases (2025% still experiencing) Dysesthesia: 8.8% incidence (mild) Body adapting well For 12mg group (final increase): GI effects may temporarily worsen (4045% nausea) Dysesthesia peaks (20.9% incidence) This is the "make or break" dose highest efficacy, highest side effects Duration: 12 weeks adjustment period Week 17+: Long-Term Maintenance Side effects: Nausea: Decreases to 1525% (down from 4045%) Diarrhea: Improves to 1020% Dysesthesia: Stable at 8.820.9% (doesn't worsen) Most people feel "normal" except for reduced appetite Key point: Side effects are WORST during dose escalation (weeks 116)
In select cases, temporary dose reduction or treatment interruption may be necessary while investigating symptoms, though this decision should be made collaboratively between patient and provider, weighing the benefits of continued therapy against symptom burden
De Block CEM, Dirinck E, Verhaegen A, Van Gaal LF
Environmental Toxins Heavy metals, pollution, and household chemicals make your body need more glutathione to clean itself out
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