Constipation is a recognized gastrointestinal side effect in major GLP-1 weight-loss trials, especially during dose escalation or when reduced appetite leads people to eat and drink less
Each pathway contributes a separate pharmacological signal: GLP-1 receptor agonism slows gastric emptying and reduces appetite signalling in the hypothalamus GIP receptor agonism enhances glucose-dependent insulin secretion and is associated in the literature with effects on lipid handling Glucagon receptor agonism increases energy expenditure and hepatic glucose output, the opposite direction to a glucagon antagonist, and is absent from every dual agonist currently on the UK market How retatrutide compares to dual agonists Tirzepatide (Mounjaro) is a GIP + GLP-1 dual agonist authorised by the MHRA for type 2 diabetes in 2023
He received his order yesterday and he said he felt it within 2 hours, no exaggeration, no bs, and he thought it was a placebo so he waited until today after work to comment and he says the second dose he took this morning before work lasted all day, close to 12 hours
---- Disclaimer: The contents of this article, including, but not limited to, text, graphics, images, and other information, is for information purposes only and does not constitute medical advice
Once again, plenty of protein is a must to avoid muscle loss