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Cloning and characterization of a family C orphan G-protein coupled receptor
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Urate, also known as uric acid, is a major endogenous antioxidant that is neuroprotective against both astrocyte-induced toxicity in SOD1 G93A mice and H 2 O 2 induced oxidative stress in cells expressing mutant SOD1 G93A (Bakshi et al., G85R cellular and Drosophila models (Zhang et al., 2019b)
Older patients and those experiencing hormonal transitions may need longer treatment courses or ongoing maintenance therapy because their underlying metabolic environment is less forgiving of medication withdrawal
