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Both Rybelsus and Januvia enhance incretin hormone activity, but through different mechanisms: Rybelsus directly activates GLP-1 receptors to stimulate insulin secretion when blood glucose levels are high, while Januvia works by preventing the breakdown of naturally occurring incretin hormones, thereby enhancing insulin secretion and suppressing glucagon release
While Ozempic is not FDA-approved specifically for weight management, it may be prescribed off-label for weight loss
Furthermore, the year of publication and dosage were found not to be a source of heterogeneity (Table 4)
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