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A long-acting peptide has to survive clearance, avoid losing activity, and keep receptor engagement in a range that doesnt either vanish (no efficacy) or spike (poor tolerability)
This gradual dose escalation helps minimise common gastrointestinal side effects such as nausea and vomiting, which are most pronounced during the initial treatment phase
Record your weight loss, changes in pain levels, and improvements in mobility or physical activity
You can lose weight with Saxenda, but it usually happens slowly and not everyone responds the same way
The difference between 21% and 29% weight loss becomes clinically significant at higher starting weights
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