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Protein misfolding in the endoplasmic reticulum as a conduit to human disease

Elevated androgens promote sebaceous gland hypertrophy and increased sebum production, creating an environment conducive to Cutibacterium acnes proliferation and inflammatory acne lesions

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No dose adjustment is required for patients with renal impairment (including end-stage renal disease) or hepatic impairment, as pharmacokinetic differences are not clinically meaningful