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This evidence comes largely from preclinical research and has not been confirmed in humans
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A clinical trial found that the combo of curcumin and CoQ10 effectively reduced the number of migraines.[ref][ref](see full article on Migraines): Article: Depression and Inflammation: A randomized clinical trial showed curcumin (500 mg/2x per day) to be more effective than a placebo for improving depression
One person on the extract and one on placebo withdrew because of side effects, and a small number of extract users cut their dose over tolerability [4]
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