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However, some scholars have proposed that the effect of GLP-1 in the liver is indirectly mediated by multiple mechanisms, such as reducing fat absorption or inhibiting fat cells through acyl-CoA synthetase long chain family member 1 (ACSL1), CCAAT/enhancer binding protein (C/EBP), peroxisome proliferator-activated receptor- (PPAR), and sterol regulatory element binding protein-1c (SREBP-1c) pathways to achieve the purpose of reducing liver lipids [38]
Reviewed by the HealthRX.com medical team
Recent research has identified the expression of GLP-1R on unconventional T cells, such as hepatic T cells [155]
In addition to GLP-1, linagliptin also increased postprandial plasma levels of GIP to a similar degree in all genotypes
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