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Research challenges Mitochondrial dysfunction is characterized by pronounced cell-type and tissue-specific differences, with distinct manifestations observed in cardiomyocytes compared to neurons

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In consideration of the reduced compliance of peptide GLP-1 receptor agonists due to subcutaneous injection, oral micromolecular GLP-1 receptor agonists such as orforglipron have already in clinical trials, which can reduce body weight and improve cardiac metabolism in adults with obesity (Wharton et al 2023) (Fig

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Their ages ranged from 1978