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It compared people taking semaglutide at the 2.4mg dose (Wegovy) in combination with lifestyle changes (diet and exercise programs) with people who only made lifestyle changes
doi: 10.1123/ijsnem.2016-0154 99
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Either way, the practical implication is similar, and it is arguably the most consequential consideration for anyone planning future work: on the brain-access hypothesis, novel dual GLP-1/GIP agonists engineered specifically for brain entry would be more rational next candidates to test than repurposed diabetes drugs chosen for market availability
Karimi, M., Pirzad, S., Hooshmand, F., Shirsalimi, N., & Pourfaraji, S
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