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During the early phase of therapy, weight loss often occurs relatively rapidly due to reduced appetite, delayed gastric emptying, and improved glycaemic control

The glucagon receptor activation adds a heart rate variable that needs monitoring

Importantly, semaglutide should not be used with other GLP-1 receptor agonists or with other semaglutide-containing products

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SLE can induce immune dysfunction which includes the production of autoantibodies and defective clearance of immune complexes, leading to multi-organ damage (Fava and Petri, 2019)