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Data extraction and quality assessment The following information was independently extracted by two researchers (WYY and YGC) from the included papers: study characteristics (first author, publication year, country, intervention, number of participants, duration of follow-up), intervention characteristics (type of GLP-1 RA, indication for treatment, dosage, treatment duration, control), primary outcomes (SMI, LBM, total-body skeletal muscle mass, walking speed, and grip strength), secondary outcomes (BW, BFM, BFR, VFA, BMI, VFL, and the incidence of adverse reactions)

Glucagon-like peptide-1 and hypothalamic regulation of satiation: cognitive and neural insights from human and animal studies

A secretagogue like Ipamorelin acts on the GHSR-1a receptor to trigger the release and, at the same time, suppresses somatostatin, the brake that normally limits GH output

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These instructions, in turn, initiate a myriad of responses, ranging from fostering muscle growth and skin rejuvenation to orchestrating the delicate balance of hormones and body weight