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It is a recombinant form of the peptide exendin-4, which is a GLP-1 receptor agonist with a 53% similarity to the gastrointestinal hormone GLP-1 and it is resistant to DPP-4 inactivation with a 140-minute half-life after subcutaneous administration allowing therapy by a twice daily administration [36]

Rybelsus Rybelsus is a semaglutide medication used to treat Type 2 diabetes in adults

Trials funded by Novo Nordisk have shown a mean weight loss of up to 15% from oral semaglutide in adults without diabetes

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