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This happens not because tirzepatide itself damages blood vessels, but because of the mechanical trauma of the injection

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J Membr Biol (1986) 90:17790

After the initial injection, Ozempic pens may be stored either in the refrigerator at 36F to 46F (2C to 8C) or at room temperature, not exceeding 86F (30C), for up to 56 days