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When the effects of age on renal function are taken into account, age alone did not have a clinically meaningful impact on the pharmacokinetics of sitagliptin based on a population pharmacokinetic analysis

However, individual responses vary considerably, and the degree of appetite suppression can differ from person to person and may fluctuate throughout treatment

Oral semaglutide bioavailability is significantly lower, estimated at 0.4 to 1% for standard oral formulations