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When activation of the HPA axis and release of adrenal hormones becomes constant or chronic, health problems develop (Anderson 2008)
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Wang Q-H, Pan S, Yang K, Wu Y-J, Cheng X-P, Olatunji OJ, Mao Q, Zuo J (2022) Glycolysis aggravates methotrexate toxicity by fueling RFC1-controlled intestinal absorption in rheumatic rats
Human Evidence Human research primarily involves topical application
Some patients experience mild gastrointestinal symptoms, particularly with oral peptides, or transient fatigue during the adjustment period
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