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Some patients experience itching or a nodule at the injection site
Despite these points, for studies where efficacy and precise control are paramount, the benefits often outweigh the logistical hurdles
Its key advantages are prolonged sterility (multi-dose use) and slight anesthetic effect, but it must be used correctly: always dilute drugs per guidelines, ensure the final solution is isotonic, and heed contraindications (no neonates, no intrathecal use)
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Once reconstituted, refrigerate for short-term use
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