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however, it should be noted that this was not a large increase, as it was only an increase of 0.2 percentage points between 2020 to 2024 (1.3% to 1.5%)
Conversely, starting at excessive doses (500+ mcg) causes unnecessary side effects prompting premature discontinuation before benefits appear
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Fukami K, Yamagishi S, Sakai K, Kaida Y, Adachi T, Ando R, Okuda S
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