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No participant withdrew from any trial due to treatment-related adverse effects
doi: 10.1016/j.tcb.2020.09.006 43 LeeJHPhelanPShinMOhBCHanXImSSet al
Cardiotoxicity attenuation has been studied in the context of bupivacaine exposure (PMID 27815173), broadening the literature beyond the conventional musculoskeletal and gastric framings
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There are no other absolute contraindications reported for hydroxocobalamin use in deficiency states, but caution is advised in individuals with conditions such as early Lebers optic neuropathy (a rare hereditary optic atrophy) due to the theoretical risk of worsening vision
