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Lifestyle modifications, including diet and exercise, remain essential
Martos et al., 2020 showed significant levels of neutrophil markers (cell free DNA, MPO and calprotectin) and lower level of natural anticoagulant activated protein C (APC) and its genetic regulators ( THBD -c.1418 T and, PROCR -H3, PROCR -H1) in patients with venous thromboembolism [63]
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Treatment often requires a multidisciplinary approach, including pharmacological interventions (e.g., anticonvulsants, muscle relaxants), non-pharmacological therapies (e.g., acupuncture, hypnosis), and, in severe cases, surgical interventions such as vagus nerve stimulation
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