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Avoid concurrent use with potent anti-inflammatories or NSAIDs if the goal is collagen rebuilding
No perimenopause-specific contraindications are formally documented, but women using concurrent HRT should consult a provider before use given potential HPA axis interactions
Among them, NOD-like receptor (NLRP3) plays a role in inflammatory body formation and activation, as well as in the regulation of transforming growth factor beta-1 (TGF1), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor ligand superfamily member 2 (TNFSF2), all of which contribute to vascular complications in diabetes [65]
Kupcova Skalnikova H, Navarro R, Marsala S, Hrabakova R, Vodicka P, Gadher SJ, et al
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